Dr. Anderson built the house in which the museum resides in 1814 in the style of Federalist Architecture. At the Anderson House, he practiced medicine, enjoyed family life, and later, opened a portion to the public as a bank. It was the first established bank between Chambersburg and Harrisburg. People would travel a large distance to find such an institution. The bank vault is still open for public viewing within our gift shop.

The Anderson house underwent major renovations from April 2016 to May 2018. Today, it is home to the Southern Alleghenies Museum of Art in Bedford. The museum features a wide range of media from student artwork to internationally recognized works by Rembrandt, Dali, Warhol, and many more. With more than 7,500 pieces in the permanent collection, exhibitions are changed quarterly which provides art lovers the opportunity to find new media with each return visit to SAMA. The museum provides activities for adults and children, provides a space for local and regional artists to exhibit, and is a tourist attraction drawing visitors from across the nation.